Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.
نویسندگان
چکیده
The development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has little effect on vincristine or daunorubicin activity in drug-sensitive parental leukemia and corrects daunorubicin resistance without altering cellular daunorubicin accumulation.
منابع مشابه
Tumor Cells Daunorubicin-resistant and -sensitive Human and Murine Daunorubicin-produced Nucleolar Protein B23 Translocation in Cyclosporin A and Verapamil Enhancement of Updated Version
It has recently been shown that anthracycline antibiotic-resistant tumor cells are less responsive to daunorubicin-stimulated B23 nucleolar phosphoprotein translocation than drug-sensitive cells. Since cyclosporin A and verapamil reverse primary acquired and secondary cross-resistance to daunorubicin, we investigated the effect of these agents on nucleolar B23 translocation in sensitive and res...
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It has recently been shown that anthracycline antibiotic-resistant tumor cells are less responsive to daunorubicin-stimulated B23 nucleolar phosphoprotein translocation than drug-sensitive cells. Since cyclosporin A and verapamil reverse primary acquired and secondary cross-resistance to daunorubicin, we investigated the effect of these agents on nucleolar B23 translocation in sensitive and res...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 77 4 شماره
صفحات -
تاریخ انتشار 1986